Bluetongue virus-induced interferon synthesis.
نویسنده
چکیده
HUlSMANS, H . Bluetongue virus-induced interferon synthesis. Onderstepoort J. vet . Res., 36 (2), 18!-186, .1969. Bluetongue virus was found to induce interferon in mouse embryo (ME) cells and in mice. Different strains of bluetongue virus differed in their ability to induce interferon. Interferon production in ME cells commences after a 5 hour lag phase and the cells continue to produce in terferon for 20 hours. Isolated double-stranded bluetongue virus RNA was found to induce maxim um t itres of interferon in mice approximately 4 hours earlier than was the case with whole virus.
منابع مشابه
Interferon induction by bluetongue virus and bluetongue virus ribonucleic acid.
EKSTEEN, P. A . L. & HUISMAN S, H. Interferon induction by bluetongue virus and bluetongue virus ribonucleic acid. Onderstep oort]. vet . R es. 39(3), 125-132 (1972). The stimulation of interferon synthesis by bluetongue virus and by bluetongue virus ribonucleic acid was investigated in order to determine if there is a difference in the mechanism of induction. The molecular mass of the interfer...
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Upon infection with Bluetongue virus (BTV), an arthropod-borne virus, type I interferon (IFN-I) is produced in vivo and in vitro. IFN-I is essential for the establishment of an antiviral cellular response, and most if not all viruses have elaborated strategies to counteract its action. In this study, we assessed the ability of BTV to interfere with IFN-I synthesis and identified the nonstructur...
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The induction of interferon and the ability of interferon to induce the antiviral state were studied using rabbit corneal epithelial and stromal cells which were cultured for fewer than five passages. Interferon titers in the range of 7000 units/ml were induced in epithelial cell cultures and 76,000 units/ml in stromal cell cultures treated with UV-inactivated bluetongue virus. The interferon i...
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ورودعنوان ژورنال:
- The Onderstepoort journal of veterinary research
دوره 36 2 شماره
صفحات -
تاریخ انتشار 1969